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Distinct from the channel opening induced by endogenous glutamate transmitter, ivermectin-activated channels open very slowly but essentially irreversibly.
As a result, neurons or muscle cells remain at either hyperpolarisation or depolarization state, thereby resulting in paralysis and death of the parasites.
Ivermectin does not readily pass the mammal blood-brain barrier to the central nervous system where glutamate-gated chloride channels locate, hence the hosts are relatively resistant to the effects of this agent.
The large-scale administration of oral ivermectin to people has become a cornerstone in the global eradication campaign against human onchocerciasis and lymphatic filariasis 5.
The recommended dose of ivermectin used to treat humans for filarial infection [i. At these plasma concentrations, ivermectin can significantly reduce the survival of Anopheles mosquitoes that ingest treated blood.
Anopheles species shown to be susceptible to ivermectin at these concentrations include major vectors from Africa Anopheles gambiae, Anopheles arabiensis , Southeast Asia Anopheles campestris, Anopheles dirus, Anopheles minimus, Anopheles swandwongporni and Latin America Anopheles aquasalis, Anopheles darlingi.
Pilot field trials in western Africa indicate that the mass drug administration of ivermectin against onchocerciasis and lymphatic filariasis can simultaneously reduce survival of Anopheles gambiae and local malaria transmission 7.
When it first appeared in the lates, ivermectin, a derivative of avermectin was a truly revolutionary drug. Despite decades of searching around the world, the Japanese microorganism Streptomyces avermitilis remains the only source of avermectin ever found 8.
Ivermectin is effective against a wide range of parasites, including gastrointestinal roundworms, lungworms, mites, lice and hornflies 9.
Ivermectin is also highly effective against ticks, for example, the ixodid tick Rhipicephalus Boophilus microplus, one of the most important cattle parasites in the tropics and subtropics, which causes enormous economic damage.
Today, ivermectin is being used to treat billions of livestock and pets around the world, helping to boost production of food and leather products, as well as keep billions of companion animals, particularly dogs and horses, healthy.
Ivermectin is so useful and adaptable that it is also being used off-label, sometimes, illegally, for example to treat fish lice in the aquaculture industry, where it can have a negative impact on non-target organisms Ivermectin also has extensive uses in agriculture Today, ivermectin is being increasingly used worldwide to combat other diseases in humans, such as Strongyloidiasis which infects some 35 million each year , scabies which causes million cases annually , Pediculosis, Gnathostomiasis and Myiasis—and new and promising properties and uses for ivermectin and other avermectin derivatives are continuing to be found These include activity against another neglected tropical disease, Leishmaniasis Of perhaps even greater significance is the evidence that the use of ivermectin has both direct and indirect beneficial impact on improving community health.
Studies of long-term treatment with ivermectin to control Onchocerciasis have shown that use of the drug is additionally associated with significant reduction in the prevalence of infection with any soil-transmitted helminth parasites including Ascaris, Trichuris and hookworm , most or all of which are deemed to be major causes of the morbidity arising from poor childhood nutrition and growth It is also known that the prevalence of head lice is markedly reduced in children taking ivermectin tablets 17 and that scabies is markedly reduced in populations taking the drug regularly In many underprivileged communities throughout the tropics, intestinal worms and parasitic skin diseases are extremely common and associated with significant morbidity.
They usually co-exist, with many individuals infected with both ecto- and endoparasites Mass treatment of poly-parasitized populations is deemed to be the best means of control and ivermectin is the ideal drug for such interventions.
A recent study in Brazil, using locally produced ivermectin, looked at the impact on internal helminthes and parasitic skin diseases. Ivermectin is typically given as one or two oral doses.
Ivermectin therapy has been associated with minor, self-limiting serum aminotransferase elevations and very rare instances of clinically apparent liver injury Ivermectin is used to treat strongyloidiasis threadworm; infection with a type of roundworm that enters the body through the skin, moves through the airways and lives in the intestines.
Ivermectin is also used to control onchocerciasis river blindness; infection with a type of roundworm that may cause rash, bumps under the skin, and vision problems including vision loss or blindness.
Ivermectin is in a class of medications called anthelmintics. It treats strongyloidosis by killing the worms in the intestines.
Ivermectin treats onchocerciasis by killing the developing worms. Ivermectin does not kill the adult worms that cause onchocerciasis and therefore it will not cure this type of infection.
Ivermectin is also sometimes used to treat certain other roundworm infections, head or pubic lice infestation, and scabies itchy skin condition caused by infestation with small mites that live under the skin.
Talk to your doctor about the risks of using this medication for your condition. Ivermectin comes as a tablet to take by mouth.
It is usually taken as a single dose on an empty stomach with water. If you are taking ivermectin to treat onchocerciasis, additional doses 3, 6, or 12 months later may be necessary to control your infection.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ivermectin exactly as directed.
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